Ann Arbor, home to the University of Michigan, ranks fifth on the report's happiness index and 17th for healthcare access.
Pittsburgh boasts affordable housing costs, a good hospital system, green areas, and courses at Carnegie Mellon and the University of Pittsburgh.
Located on the Ohio-Pennsylvania border, Youngstown features more than 5,000 acres of nature trails and lakes.
The only Florida city in the top 11, Daytona Beach, ranked seventh on the list for desirability.
York, located about 20 miles from Pennsylvania's border with Maryland, ranked fifth on the list for access to quality healthcare.
Despite a high cost of living, New York City ranks first on the list for healthcare, as well as sixth for happiness due to its many world-class restaurants, museums, parks, and theaters.
Allentown, 60 miles northwest of Philadelphia, offers fourth-best healthcare and lower housing expenses than many of its neighbors.
Scranton, located about two hours from both New York City and Philadelphia, has a high percentage of residents over 65.
Scranton, located about two hours from both New York City and Philadelphia, has a high percentage of residents over 65.